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S0130 | CAS:18883-66-4 | Streptozocin | 链脲佐菌素
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S0130 Streptozocin
Sigma ≥75% α-anomer basis, ≥98% (HPLC), powder
窗体底端
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货号
号 |
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目录价
RMB |
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S0130-1G |
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2,351.70 |
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Synonym: |
Streptozotocin, N-(Methylnitrosocarbamoyl)-α-D-glucosamine |
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CAS Number: |
18883-66-4 |
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Empirical Formula (Hill Notation): |
C8H15N3O7 |
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Molecular Weight: |
265.22 |
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Beilstein Registry Number: |
2060675 |
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EC Number: |
242-646-8 |
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MDL number: |
MFCD00006607 |
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PubChem Substance ID: |
24899428 |
Description
| Frequently Asked Questions |
Live Chat and Frequently Asked Questions are available for this Product. |
| Application |
Streptozocin is used to induce Type 1 diabetes for medical research. |
| General description |
Streptozotocin, a glucosamine-nitrosourea, is a DNA alkylating agent that enters cells exclusively via the GLUT2 glucose transport protein. Streptozocin, a diabetagen, is especially toxic to pancreatic islet insulin-producing β-cells. It is toxic to GLUT2 positive neuroendocrine tumor cells. |
| Other Notes |
Mixed anomers |
| Biochem/physiol Actions |
An N-nitroso-containing compound that acts as a nitric oxide donor in pancreatic islets; induces death of insulin-secreting cells, producing an animal model of diabetes. Potent DNA methylating agent that induces chromosomal breakage.1 Cytotoxic to neuroendocrine tumor cell lines that express the GLUT2 glucose transporter. |
性质
| assay |
≥75% α-anomer basis |
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≥98% (HPLC) |
| form |
powder |
| color |
white to off-white |
| mp |
121 °C (dec.)(lit.) |
| storage temp. |
−20°C |
安全性
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